Are persons living with diagnosed HIV capable of mounting a strong inflammatory response to the new coronavirus?
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background The impact of COVID-19 on persons living with diagnosed HIV (PLWDH) remains incompletely understood. It’s unclear whether an impaired immune system offers protection against mounting cytokine storm. Methods Retrospective matched cohort study of COVID-19 hospitalized individuals in New York State (NYS). Medical records were abstracted and analyzed for 853 PLWDH hospitalized with COVID-19 in NYS and 1621 HIV-negative controls. Preexisting comorbidities and inflammatory markers measured within 24 h of hospital admission were abstracted. Results PLWDH were significantly less likely to have elevated inflammatory markers compared to matched controls. Elevated WBC occurred in 23.3% of PLWDH vs 30.1% of controls ( p = .0002), elevated CRP in 37.4% of PLWDH vs 43.2% of controls ( p = .03), elevated ferritin in 73.4% of PLWDH vs 78.9% of controls ( p = .004). There was an inverse but not statistically significant relationship between the frequency of elevated inflammatory markers and HIV disease stage, with greatest percent of PLWDH with elevated WBC, LDH, CRP, and ferritin among PLWDH with HIV disease stage 1. Conclusion PLWDH had lower inflammatory marker elevation during COVID-19 infection compared to matched controls. PLWDH with low CD4 were less likely to mount a cytokine storm in the setting of impaired immune function.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4385295366