FIGURE 2 from Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
Year: 2023
Type: other
Abstract: X15695 attenuates ERα-mediated target gene expression. GSEA plots of the top gene sets identified in a comparison of E2 + X15695 versus E2 (A) and X15695 versus vehicle (B) in MCF-7. C–H, Quantitative RT-PCR to detect the effect of X15695 on the expression of the indicated p53 target genes in MCF-7 cells in the presence and absence of E2. Cells were treated with the indicated concentrations of X15695 in the presence and absence of 10 nmol/L E2 for 16 hours. The data represent the mean ± SEM (n = 4; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; ns, not significant).
Authors: Mengwu Pan, Valeria Solozobova, Nane C. Kuznik, Nicole Jung, Simone Gräßle, Victor Gourain, Yvonne M. Heneka, Christina A. Cramer von Clausbruch, Olaf Fuhr, Ravi S. N. Munuganti, Danilo Maddalo, Christine Blattner, Antje Neeb, Adam Sharp, Laura Cato, Carsten Weiss, Rinath M. Jeselsohn, Veronique Orian-Rousseau, Stefan Bräse, Andrew C. B. Cato
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4385303142