Work

Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling

Year: 2023

Type: article

Abstract: A specific genetic variant associated with atrial fibrillation risk, rs17171731, was identified as a regulatory variant responsible for controlling FAM13B expression. The atrial fibrillation risk allele decreases FAM13B expression, whose knockdown alters the expression of many genes in stem cell–derived cardiomyocytes, including SCN2B, and led to pro-arrhythmogenic changes in the late sodium current and Ca2+ cycling. Fam13b knockout mice had increased P-wave and QT interval duration and were more susceptible to pacing-induced arrhythmias vs control mice. FAM13B expression, its regulation, and downstream effects are potential targets for investigation of patient-specific therapeutics.

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2023.05.009

Authors: Gregory Tchou, Daniela Ponce-Balbuena, Nana Liu, Shamone Gore-Panter, Jeffrey Hsu, Fang Liu, Emmanuel Opoku, Gregory Brubaker, Sarah M. Schumacher, Christine S. Moravec, John Barnard, David R. Van Wagoner, Mina K. Chung, Jonathan D. Smith

Institutions: Cleveland Clinic, The Ohio State University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,530

Funders: U.S. Department of Veterans Affairs, American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences

Awards: Translational Strategies for the Prevention of Atrial Fibrillation Development and Progression, G3541864657, RADIOMIC APPROACHES TO IMPROVE TARGETING FOR ATRIAL FIBRILLATION CATHETER ABLATION, G7588057132, Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages for Everyone's Health (CLE Health), Atrial Fibrillation Post-GWAS: Mechanisms to Treatment

OpenAlex ID: W4385307445

FWCI: 1.179

Cites: 50

Cited by: 6

Related to: 10