Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain
Year: 2023
Type: article
Abstract: The blood-brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals, cannot reach their targets in the brain. Notwithstanding the remarkable advances in characterizing the cellular nature of the BBB and consequences of BBB dysfunction in pathology (brain metastasis, neurological diseases), it remains challenging to deliver drugs to the CNS. Herein, we outline the basic architecture and key molecular constituents of the BBB. In addition, we review the current status of approaches that are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few other important key considerations that can improve our understanding about the dynamics of the BBB.
Source: Cell & Bioscience
Institutions: University Hospital Bonn, 3B's Research Group, University of Minho, Warsaw University of Life Sciences, Center for Translational Medicine, University of Otago, Mossakowski Medical Research Institute, Polish Academy of Sciences, Polish Academy of Sciences, University of Maryland, Baltimore, City Of Hope National Medical Center, City of Hope, Beckman Research Institute
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,790
Funder: Interreg
Award: G1188750917
OpenAlex ID: W4385308165