Type 1 diabetes genetic risk score differentiates subgroups of Ketosis-Prone Diabetes
Year: 2023
Type: other
Abstract: Objective: To determine if genetic risk for type 1 diabetes (T1D) differentiates the four “Ab” subgroups of Ketosis-Prone Diabetes (KPD), where “A+” and “A-” define presence or absence of islet autoantibodies and “b+” and “b-” define presence or absence of beta cell function. Research Design and Methods: We compared T1D genetic risk scores (GRS) of KPD patients across subgroups, race/ethnicity, beta cell function and glycemia. Results: Among 426 KPD patients (54% Hispanic, 31% African American, 11% White), rank-order of GRS was A+b- > A+b+ = A-b- > A-b+. GRS of A+b- KPD was lower than that of a T1D cohort and GRS of A-b+ KPD was higher than that of a T2D cohort. GRS was lowest among African American patients with a similar distribution across KPD subgroups. Conclusions: T1D genetic risk delineates etiological differences between KPD subgroups. A+b- KPD patients have the highest and A-b+ KPD patients the lowest GRS.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4385334282