Thermophobic Trehalose Glycopolymers as Smart C‐Type Lectin Receptor Vaccine Adjuvants (Adv. Healthcare Mater. 19/2023)
Year: 2023
Type: article
Abstract: Thermoresponsive Polymers Adjuvant additives enhance the efficacy of many vaccines, however, their use must be judiciously tailored because adjuvants also cause inflammatory side effects such as pyrexia. In article 2202918, Rock J. Mancini and co-workers create thermophobic vaccine adjuvants that attenuate activity at increased temperatures correlating to that experienced during mild pyrexia. These thermophobic adjuvants remain effective in vivo where they improve the efficacy of a model Influenza vaccine resulting in enhanced neutralizing antibodies and memory T-cells as well as reduced morbidity upon viral re-challenge. Overall, this technology presents a new way to create adjuvants that enhance vaccine efficacy while simultaneously limiting inflammatory side effects.
Source: Advanced Healthcare Materials
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4385358339