Work

Supplementary Figure S3 from A pilot study of neoadjuvant nivolumab, ipilimumab and intralesional oncolytic virotherapy for HER2-negative breast cancer

Year: 2023

Type: supplementary-materials

Abstract: Detection of talimogene laherparepvec (T-VEC) vector reads in case #2. This screenshot from the integrated genomics viewer shows reads aligning to CSF2 (GM-CSF) from the peripheral blood, baseline, and end-of-treatment (EOT) whole exome sequencing (WES) data from the surgical specimen of case #2. The short-clipped ends of the reads at the 5’ end of CSF2 contained the T-VEC cytomegalovirus (CMV) promoter sequence, and reads spanned the exon-exon junctions of the CSF2 transcript. This pattern was not observed in the surgical (EOT) specimens from the other patients or in baseline samples.

DOI: 10.1158/2767-9764.23791814.v1

Authors: Vina P Nguyen, Katie M. Campbell, Theodore S Nowicki, Nila Elumalai, Egmidio Medina, Ignacio Baselga-Carretero, Maggie L DiNome, Helena R. Chang, Denise K Oseguera, Antoni Ribas, John A. Glaspy

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4385368268

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