P10-002-23 Precision Nutrition: Is the Hype is Exceeding the Science and Evidentiary Standards Needed To Inform Public Health Recommendations for Prevention of Chronic Disease?
Year: 2023
Type: article
Abstract: analyzed by HPLC-MS/MS (SCIEX 6500).Genotypes related to lactase-persistence were determined with a customized multiarray (Illumina).A two-sided t test was used to compare amounts by genotype.Results: The 18 adults with the TT genotype ( presumably with high lactase activity) excreted about twice the amount of anthocyanin-derived phenolic compounds than the 12 participants with the non-persistent CC genotype (787 versus 391 nmoles/24 hours, p = 0.006).Similar genotype-related differences were seen for hippuric acid alone (360 versus 202 nmoles/ 24 h, p = 0.016), 3-OH hippuric acid (36.2 versus 12.7 nmoles/ 24 h, p = 0.017), and 3-OH phenylacetic acid (47.4 versus 32.9 nmoles/24 h, p = 0.077).Conclusions: The observation that ingestion of the same dose of anthocyanins results in much higher excretion of the typical phenolic metabolites in adults with the high-lactase genotype than in those with the low-lactase genotype Is consistent with the initial hypothesis.Since it is likely that many of the benefits of anthocyanins and other glucoside flavonoids are related to small metabolites derived from the ingested bioactives, greater produced and excreted amounts may well indicate a greater health benefit.Future investigations of relevant fruit and vegetable effects and of flavonoid intake recommendations must consider the likely consequence of presence versus absence of lactase persistence, particularly considering the greatly differing frequencies in diverse populations.
Authors: Regan Bailey, Patrick Stover
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,000
OpenAlex ID: W4385401989