Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation
Year: 2023
Type: article
Study design: Observational Study
Abstract: Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and trauma patients. We report low concordance between circulating and fecal SCFAs, significant postprandial changes in most circulating SCFAs, and a heritable genetic component (average h2: serum = 14%(SD = 14%); stool = 12%(SD = 6%)). Furthermore, we find that gut microbiome can accurately predict their fecal levels (AUC>0.71) while presenting weaker associations with serum. Finally, we report different correlation patterns with inflammatory markers depending on the type of inflammatory response (chronic or acute trauma). Our results illustrate the breadth of the physiological relevance of SCFAs on human inflammatory and metabolic responses highlighting the need for a deeper understanding of this important class of molecules.
Source: Gut Microbes
Authors: Ana Nogal, Francesco Asnicar, Amrita Vijay, Afroditi Kouraki, Alessia Visconti, Panayiotis Louca, Kari Wong, Andrei-Florin Baleanu, Francesca Giordano, Jonathan Wolf, George Hadjigeorgiou, Richard Davies, Gregory A. Michelotti, Paul W. Franks, Sarah E. Berry, Mario Falchi, Adeel Ikram, Benjamin J. Ollivere, Amy Zheng, Jessica Nightingale, Massimo Mangino, Nicola Segata, William J. Bulsiewicz, Tim D. Spector, Ana M. Valdes, Cristina Menni
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,060
Funders: National Institute on Handicapped Research, King’s College London, Wellcome Trust, Chronic Disease Research Foundation, UK Research and Innovation, National Institute for Health and Care Research, British Heart Foundation, Diabetes UK, King's College London, European Commission, Horizon 2020 Framework Programme, Medical Research Council, NIHR Nottingham Biomedical Research Centre
Awards: G1786533719, G2335242333, The ORiF (Operative Rib Fixation) Procedure mEchanisms of Rib fixAtion (OPERA) STUDY, G2797676348, G2900784964, G2960067629, G3034773854, G3116035892, G3262677843, G3371442618, G3531710099, Molecular signatures of endocannabinoid induced pain relief in humans: lifestyle interventions, systemic and localised changes., G3759785120, Metabolomics of faecal samples to identify markers of type 2 diabetes incidence, G4237468453, G4339104721, G4780888793, G4937468798, TwinsUK (2019-2023) - An Epidemiological and Genomic Resource, A Systems medicine approach to chronic inflammatory disease, G620726348, Evaluation of chest wall stabilisation through Operative RIb Fixation (ORIF Study), TwinsUK (2019-2023) - An Epidemiological and Genomic Resource, G6900034347, MICA: Ancestry and biological Informative Markers for stratification of HYpertension: The AIM HY study, G721613800, G7329132729, G7722851534, G7987313117, G8303031892, G8888865168
OpenAlex ID: W4385441904