Figure 1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer
Year: 2023
Type: other
Abstract: Loss of Btnl1 increases adenoma formation in Apc-deficient mouse models. A, Images of SI from VA and VA;Btnl1—/— mice stained for Btnl1 mRNA representative of 4/group; scale bar, 100 μm. B, Images of SI from VA and VA;Btnl1—/— mice stained for Trdc mRNA; scale bar, 500 μm. γδ T-cell numbers in SI of indicated models. Each dot represents one mouse (n = 3). C, Kaplan–Meier survival analysis of VA (n = 15) and VA;Btnl1—/— (n = 6) mice. D, Tumor number and tumor burden (mm2) in SI and colon of VA and VA;Btnl1—/— mice. Each dot represents one mouse (n = 15 VA, 6 VA;Btnl1—/— mice). Data are presented as mean ± SD. *, P < 0.05; ***, P < 0.001 (unpaired t test).
Authors: Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor, Anastasia Georgakopoulou, Hannah Hayman, Kyi Lai Yin Swe, Anna Nordin, Claudio Cantù, Pierre Vantourout, Rachel A. Ridgway, Ryan M. Byrne, Lei Chen, Michael P. Verzi, David M. Gay, Ester Gil Vázquez, Hayley L. Belnoue-Davis, Kathryn Gilroy, Anne Helene Køstner, Christian Kersten, Chanitra Thuwajit, Ditte K. Andersen, Robert Wiesheu, Anett Jandke, Karen Blyth, Antonia K. Roseweir, Simon J. Leedham, Philip D. Dunne, Joanne Edwards, Adrian Hayday, Owen J. Sansom, Seth B. Coffelt
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4385549630