Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY DESIGN: Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age. RESULTS: We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56-2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics. CONCLUSION: Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. GOV ID: Term Reference (under the Generic Database Study): NCT00063063.
Source: Journal of Perinatology
Authors: Charles E. Green, Jon E. Tyson, Roy J. Heyne, Susan R. Hintz, Betty R. Vohr, Carla M. Bann, Abhik Das, Edward F. Bell, Sana Boral Debsareea, Emily Stephens, Marie G. Gantz, Carolyn M. Petrie Huitema, Karen J. Johnson, Kristi L. Watterberg, Ricardo Mosquera, Myriam Peralta-Carcelen, Deanne E. Wilson-Costello, Tarah T. Colaizy, Nathalie L. Maitre, Stephanie L. Merhar, Ira Adams-Chapman, Janell Fuller, Michelle E. Hartley-McAndrew, William F. Malcolm, Sarah Winter, Andrea F. Duncan, Gary J. Myer, Stephen D. Kicklighter, Myra H. Wyckoff, Sara B. DeMauro, Anna Maria Hibbs, Barbara J. Stoll, Waldemar A. Carlo, Krisa P. Van Meurs, Matthew A. Rysavy, Ravi M. Patel, Pablo J. Sánchez, Abbot R. Laptook, C. Michael Cotten, Carl T. D’Angio, Michele C. Walsh, Richard A. Polin, Martin Keszler, Angelita M. Hensman, Elisa Vieira, Lucille St. Pierre, Robert T. Burke, Barbara Alksninis, Andrea Knoll, Mary L. Keszler, Teresa M. Leach, Elisabeth C. McGowan, Victoria E. Watson, Nancy S. Newman, Bonnie S. Siner, Elizabeth Roth, Angelia Williams, Brenda B. Poindexter, Kurt Schibler, K. Tanya E. Cahill, Cathy Grisby, Kristin Kirker, Sara Stacey, Sandra Wuertz, Ronald N. Goldberg, Ricki F. Goldstein, Patricia L. Ashley, Deesha Mago-Shah, Joanne Finkle, Kimberley A. Fisher, Kathryn E. Gustafson, Caitlin Stone, Matthew M. Laughon, Janice Bernhardt, Janice Wereszczak, Jennifer Talbert, Alexandra Bentley, Laura Edwards, Ginger Rhodes-Ryan, Donna White, David P. Carlton, Yvonne Loggins, Diane Bottcher, Sheena L. Carter, Salathiel Kendrick-Allwood, Maureen Mulligan LaRossa, Judith Laursen, Colleen Mackie, Amy Sanders, Gloria Smikle, Lynn Wineski, Andrew A. Bremer, Rosemary D. Higgins, Stephanie Wilson Archer, Amir M. Khan, Kathleen A. Kennedy, Andrea F. Duncan, Elizabeth Allain, Julie Arldt-McAlister, Fatima Boricha, Allison G. Dempsey, Carmen Garcia, Donna J. Hall, Janice John, M. Layne Lillie, Karen Martin, Georgia E. McDavid, Shannon L. McKee, Michelle Poe, Kimberly Rennie, Tina Reddy, Shawna Rodgers, Daniel K. Sperry, Sharon L. Wright, Leif D. Nelin, Jonathan L. Slaughter, Sudarshan R. Jadcherla, Christopher Timan, Patricia Luzader, Melanie Stein, Rox Ann Sullivan, Helen Carey, Stephanie Burkhardt, Mary Ann Nelin, Erna Clark, Kristi Small, Jacqueline McCool, Lindsay Pietruszewski, Jessica Purnell, Kyrstin Warnimont, Laura Marzec, Bethany Miller, Demi R. Beckford, Hallie Baugher, Katelyn Levengood, Nancy Batterson, Jill Tonneman, Krystal Hay, Brittany DeSantis, Dennis Wallace, Jeanette O’ Donnell Auman, Margaret Crawford, Jenna Gabrio, Jamie E. Newman, Lindsay Parlberg, Kristin M. Zaterka-Baxter, David K. Stevenson, M. Bethany Ball, Valerie Chock, Dona Bahmani, Barbara Bentley, Maria Elena DeAnda, Anne M. DeBattista, Beth Earhart, Lynne C. Huffman, Casey E. Krueger, Ryan E. Lucash, Heather Taylor, Hali E. Weiss, Namasivayam Ambalavanan, Kirstin J. Bailey, Fred J. Biasini, Stephanie A. Chopko, Monica V. Collins, Shirley S. Cosby, Kristy A. Domnanovich, Chantel J. Jno-Finn, Morissa Ladinsky, Mary Beth Moses, Tara E. McNair, Vivien A. Phillips, Julie Preskitt, Richard V. Rector, Kimberlly Stringer, Sally Whitley, Sheree York Chapman, Heidi M. Harmon, Karen J. Johnson, Mendi L. Schmelzel, Jacky R. Walker, Claire A. Goeke, Sarah E. Faruqui, Diane L. Eastman, Michelle L. Baack, Laurie A. Hogden, Megan M. Henning, Chelsey Elenkiwich, Megan Broadbent, Sarah Van Muyden, Robin K. Ohls, Conra Backstrom Lacy, Sandra Sundquist Beauman, Mary Ruffner Hanson, Jean R. Lowe, Elizabeth Kuan, Eric C. Eichenwald, Barbara Schmidt, Haresh Kirpalani, Soraya Abbasi, Aasma S. Chaudhary, Toni Mancini, Jonathan Snyder, Kristina Ziolkowski, Ronnie Guillet, Satyan Lakshminrusimha, Anne Marie Reynolds, Rosemary L. Jensen, Joan Merzbach, William Zorn, Osman Farooq, Gary J. Myers, Mary Rowan, Diane Prinzing, Melissa Bowman, Ann Marie Scorsone, Kyle Binion, Constance Orme, Premini Sabaratnam, Alison Kent, Rachel Jones, Elizabeth Boylin, Emily Li, Jennifer Kachelmeyer, Kimberly G. McKee, Kelly R. Coleman, Brenna Cavanaugh, Luc P. Brion, Diana M. Vasil, Sally S. Adams, Frances Eubanks, E. Rebecca McDougald, Lara Pavageau, Pollieanna Sepulveda, Alicia Guzman, Elizabeth Heyne, Lizette E. Lee, Azucena Vera, Jillian Waterbury, Cathy Twell Boatman, Bradley A. Yoder, Mariana Baserga, Roger G. Faix, Stephen D. Minton, Mark J. Sheffield, Carrie A. Rau, Shawna Baker, Susan Christensen, Sean D. Cunningham, Jennifer O. Elmont, Becky Hall, Erika R. Jensen, Manndi C. Loertscher, Trisha Marchant, Kandace M. McGrath, Hena G. Mickelsen, Galina Morshedzadeh, D. Melody Parry, Kelly Stout, Ashley L. Stuart, Kimberlee Weaver-Lewis
Institutions: The University of Texas Health Science Center at Houston, The University of Texas Southwestern Medical Center, Lucile Packard Children's Hospital, Stanford University, Brown University, Women & Infants Hospital of Rhode Island, RTI International, University of Iowa, University of New Mexico Health Sciences Center, Memorial Hermann, University of Alabama at Birmingham, Rainbow Babies & Children's Hospital, Case Western Reserve University, Nationwide Children's Hospital, The Ohio State University, University of Cincinnati, Emory University, Children's Healthcare of Atlanta, University of New Mexico, University at Buffalo, State University of New York, Duke University, University of Utah, Pennsylvania Hospital, University of Rochester Medicine, University of Rochester, WakeMed, University of Pennsylvania, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Columbia University, Cincinnati Children's Hospital Medical Center, Good Samaritan Hospital, Duke Regional Hospital, Duke University Hospital, Grady Memorial Hospital, Emory University Hospital Midtown, Riverside Methodist Hospital, The Ohio State University Wexner Medical Center, Abigail Wexner Research Institute, El Camino Hospital, Children's Hospital of Philadelphia, Hospital of the University of Pennsylvania, Golisano Children's Hospital, Parkland Health & Hospital System, Children's Medical Center, Primary Children's Hospital, McKay Dee Hospital, Intermountain Medical Center, Utah Valley Regional Medical Center
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Awards: G1029946750, G1035361083, G1037055288, G1186807586, G1352838917, G1421780561, G1442547618, G1533337087, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal ResearchNetwork, G158642924, Neonatal Research Network Data Coordinating Center (DCC) 2023-2028, G1633855309, G1655184841, G1658985302, G1793787542, G1801374632, Clinical Center for NICHD/Neonatal Research Network, G1972173448, G1981379474, G2001941347, Neural basis of language trajectories in extremely preterm children, Rochester-Buffalo Neonatal Research Group, G2245156834, G2366643028, NICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORK, G245809433, Duke CTSA (Composite), G2662517073, G2680676337, G2715018881, G2965071914, G3042997015, G3128406445, G3189020257, G3360186718, G3399879591, G3547804312, G3566384843, G3611579263, G3630517034, G3654557411, G3945656891, G4107767074, G4408328601, G4423566278, G4505422504, G4556804672, G4613615020, G4621247372, G4682061961, G4806644855, G4871569943, G4881643641, G4923448371, G502544683, G5028210595, G5033150653, G5173431040, MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS, G5277386483, G5422669700, G5425378458, G5530785449, G5719355690, G6111235625, G6149667125, G6198151190, NICHD Cooperative Multicenter Neonatal Research Network, G6229692350, G6239958052, G6279089317, G6315228394, G6474410671, G6481205343, G6521818577, G6726963199, G6824599950, G6827789451, G6827829896, G7054807377, G7062581524, G7417610757, G7448329892, G7503077049, G761304568, G7614407291, G7714972198, G7792775406, NICHD Neonatal Research Network, G807757620, Multicenter Network of Neonatal Intensive Care Units-University of Texas at Houston (UT Houston) Clinical Center, G8255031621, G8323546003, G8429169078, G8485215240, G8496289185, G8621868819, G8670042916, Multicenter Network of Neonatal Intensive Care Units, G8984540923, G9000244971, G9000353486, NICHD Neonatal Research Network Clinical Center UAB, NICHD Cooperative Multicenter Neonatal Research Network - Utah Center, NICHD Neonatal Research Network - Stanford University, NICHD Neonatal Research Network, G918099212, North Carolina Clinical Center
OpenAlex ID: W4385576280