FIGURE 7 from Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment
Year: 2023
Type: other
Abstract: Combination therapy synergistically promoted monocyte to the M1 trajectory in the TME. A, Pseudotime plot of macrophage subsets constructed by Monocle 3. B, UMAP showing macrophages, neutrophils, and monocytes. C, Bar plot of the proportions of the above cell subsets. D, Dot plot showing expression levels of Il21r on different macrophage subsets under different treatment conditions. E–G, Heat map showing the expression of selected DEG in monocytes, TAM1, TAM2 cells under different treatment conditions.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4385576906