FIGURE 1 from Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment
Year: 2023
Type: other
Abstract: IL21 is produced by both CXCR5+ Tfh cells and hyperactivated/exhausted CD4+ T cells in the TME. A and B, Dot plots and UMAPs showing the expression of selected genes in different CD4+ T-cell subsets in integrated human cancer tissues. C and D, Dot plots and UMAPs showing the expression of selected genes in different CD4+ T-cell subsets in mouse MC38 colon adenocarcinoma tumors. E, UMAP plot showing imputed expression of selected genes constructed by ArchR.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4385577523