FIGURE 2 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer
Year: 2023
Type: other
Abstract: A and B, Representative IHC staining for CEACAM5 including a mixed foci harboring both NEPC (left) and CRPC (right) that stained positive and negative for CEACAM5, respectively (A) and RHAMM (B) in NEPC and in other tissue samples types from serial sections used in this study (scale bar = 50 μm). A, Right: CEACAM5 IHC expression patterns (negative, focal, or diffuse) on TMAs stratified by tissue type (benign prostate, n = 14; CRPC, n = 26; NEPC, n = 16). C, Combined t-distributed stochastic neighbor embedding (t-SNE) plot of scRNA-seq data from intact PRN (n = 3) mice. Shown are the expression of indicated markers or signature in PR (n = 3) compared to PRN GEM (n = 3) mice. D, RNA-seq FPKM values of the indicated genes which were significantly deregulated in PRN adenocarcinoma or poorly differentiated/NEPC tumors. *, P < 0.05; **, P < 0.01; ***, P < 0.0001 (Students t test).
Authors: Lucie Van Emmenis, Sheng-Yu Ku, Kaitlyn Gayvert, Jonathan R. Branch, Nicholas J. Brady, Subhasree Basu, Michael Russell, Joanna Cyrta, Aram Vosoughi, Verena Sailer, Hussein Alnajar, Etienne Dardenne, Elena Koumis, Loredana Puca, Brian D. Robinson, Michael D. Feldkamp, Annmarie Winkis, Nathan Majewski, Brent Rupnow, Marco M. Gottardis, Olivier Elemento, Mark A. Rubin, Himisha Beltran, David S. Rickman
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4385580783