FIGURE 4 from The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer
Year: 2023
Type: other
Abstract: A, Final tumor weights and images of WCM154-sgGFP and WCM154-sgCELSR3 PDOX models. B, H&E and IHC staining of indicated markers (scale bar: 50 μm) from serial sections. C, Multiplex immunofluorescence of lineage markers of sgGFP and sgCELSR3 PDOXs. D, Top gene sets enriched from the GSEAs of the RNA-seq data analyses from the sgCELSR3 PDOX laser capture cells (red) compared with sgGFP captured cells (blue). Right: GSEA enrichment plots of Bosco epithelial differentiation gene set or the GO_Main_Axon gene set enriched sgCELSR3 PDOX laser capture cells or the sgGFP captured cells, respectively. E, Normalized RNA-seq counts obtained for the indicated gene in sgCELSR3 PDOX laser capture cells (red) or the sgGFP captured cells (blue).
Authors: Lucie Van Emmenis, Sheng-Yu Ku, Kaitlyn Gayvert, Jonathan R. Branch, Nicholas J. Brady, Subhasree Basu, Michael Russell, Joanna Cyrta, Aram Vosoughi, Verena Sailer, Hussein Alnajar, Etienne Dardenne, Elena Koumis, Loredana Puca, Brian D. Robinson, Michael D. Feldkamp, Annmarie Winkis, Nathan Majewski, Brent Rupnow, Marco M. Gottardis, Olivier Elemento, Mark A. Rubin, Himisha Beltran, David S. Rickman
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4385584087