Work

Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility

Year: 2023

Type: preprint

Abstract: Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2023.08.03.551847

Authors: Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green