Work

An unstructured proteasome inhibitor comes into focus

Year: 2023

Type: article

Abstract: The inhibitory mechanism of an intrinsically disordered proteasome inhibitor identified over 30 years ago has finally been revealed by cryo-electron microscopy by Hsu et al. in a recent report in the Journal of Biological Chemistry. The structure, coupled with biochemical and cell-based experiments, resolves lingering questions about how the inhibitor achieves multisite inhibition of proteasomal protease activity, while raising several exciting new questions on the nature of proteasome subpopulations in the process.

Source: Journal of Biological Chemistry

DOI: 10.1016/j.jbc.2023.105145

Authors: Antonia A. Nemec, Robert J. Tomko

Institution: Florida State University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,800

Funders: Florida Department of Health, National Institutes of Health, National Institute of General Medical Sciences