Year: 2023
Type: article
Abstract: SignificanceThe vocal folds are critically important structures within the larynx which serve the essential functions of supporting the airway, preventing aspiration, and phonation. The vocal fold mucosa has a unique multilayered architecture whose layers have discrete viscoelastic properties facilitating sound production. Perturbations in these properties lead to voice loss. Currently, vocal fold pliability is inferred clinically using laryngeal videostroboscopy and no tools are available for in vivo objective assessment.AimThe main objective of the present study is to evaluate viability of Brillouin microspectroscopy for differentiating vocal folds’ mechanical properties against surrounding tissues.ApproachWe used Brillouin microspectroscopy as an emerging optical imaging modality capable of providing information about local viscoelastic properties of tissues in noninvasive and remote manner.ResultsBrillouin measurements of the porcine larynx vocal folds were performed. Elasticity-driven Brillouin spectral shifts were recorded and analyzed. Elastic properties, as assessed by Brillouin spectroscopy, strongly correlate with those acquired using classical elasticity measurements.ConclusionsThese results demonstrate the feasibility of Brillouin spectroscopy for vocal fold imaging. With more extensive research, this technique may provide noninvasive objective assessment of vocal fold mucosal pliability toward objective diagnoses and more targeted treatments.
Source: Journal of Biomedical Optics
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,675
Funders: National Science Foundation, U.S. Department of Defense, National Aeronautics and Space Administration, Cancer Prevention and Research Institute of Texas, National Institutes of Health, U.S. Food and Drug Administration, Biomedical Advanced Research and Development Authority, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, Division of Civil, Mechanical and Manufacturing Innovation, Air Force Office of Scientific Research
Awards: G142958786, G1523888516, MONITORING OF MAST CELL ACTIVATION FOR CONTROL OF HEALTH STATUS IN MILITARY PERSONNEL, TAS::57 3600::TAS "(MURI-15) NANOELECTROPULSE-INDUCED ELECTROMECHANICAL SIGNALING AND CONTROL OF BIOLOGICAL SYSTEMS", Novel Computer Aided Diagnosis System For Early Detection Of Oral Cancer Based On Quantitative Autofluorescence Imaging, G3546748347, G36446433, G3722112304, G392768340, G4243936892, Experimental and Theoretical Study of Femtosecond Microscale 3D Light Field Projection and Its Application in Multiphoton 3D Light Field Lithography, G567078433, G5729145195, G7456149010, G762138976, G7658023295, Brillouin Microscope for Biomedical Research, Sensing local nano-environment with coherent Raman microspectroscopy, G9000296584
OpenAlex ID: W4385660374