Supplementary Figure S3 from Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
Year: 2023
Type: supplementary-materials
Abstract: Hi-C interaction and TAD map of G7 region. The chromatin confirmation of the G7 region across the 3 HMCLs (U266, RPMI8226, and KMS11) and PC for comparison. The local TAD structure around the ABL2 locus appears conserved across the samples suggesting the additional gene dosage as a result of the CNV gain is likely the cause of the overexpression.
Authors: Eileen M. Boyle, Patrick Blaney, James H. Stoeckle, Yubao Wang, Hussein Ghamlouch, Dylan Gagler, Marc Braunstein, Louis Williams, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, Jason Avigan, Alexander Li, Monica Jinsi, David Kaminetzsky, Arnaldo Arbini, Lydia Montes, Jill Corre, Even H. Rustad, Ola Landgren, Francesco Maura, Brian A. Walker, Michael Bauer, Benedetto Bruno, Aristotelis Tsirigos, Faith E. Davies, Gareth J. Morgan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4385665302
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