Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1 -Positive Endothelial Cells
Year: 2023
Type: article
Abstract: Nonspecific interstitial pneumonia (NSIP) is an interstitial lung injury pattern, which can arise idiopathically or secondary to other causes (e.g., connective tissue diseases or drug toxicity).Histologically, fibrotic NSIP (fNSIP) is characterized by uniform widening of the alveolar septa due to homogeneous mild fibrosis with or without inflammation, while the lung architecture remains preserved (1, 2).Recently, we have reported an increased vessel diameter of the capillary network and increased intervascular distances in NSIP compared with control subjects (3), suggesting a vascular contribution to the pathogenesis of fNSIP.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, Yale University, Deutsche Forschungsgemeinschaft, National Natural Science Foundation of China, Else Kröner-Fresenius-Stiftung, Medizinischen Hochschule Hannover, Niedersächsisches Ministerium für Wissenschaft und Kultur, National Institutes of Health, Horizon 2020 Framework Programme, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences, H2020 European Research Council
Awards: Age-related Changes in the Pulmonary Artery, G1508691454, G1798727233, G2009470682, G2161961490, G23728244, G293481445, G3917534307, Epithelial Protective Effects of Thyroid Hormone Signaling in Fibrosis, G4450818189, KFO 311: (Prä)terminales Herz und Lungenversagen: mechanische Entlastung und Reparatur, G5682735249, Host-microbiome interactions after lung transplantation and chronic lung allograft dysfunction, G6881567127, Mir-29 mimicry as a therapy for pulmonary fibrosis, Mitochondrial DNA and TLR9 in Pulmonary Fibrosis, Macrophage driven, profibrotic adrenergic nerve remodeling in SSc-ILD, G7944295140, Normal Aging Lung Cell Atlas (NALCA), Hanover experimental lung research project, G8858395165, G8964729170, Genomic Analysis of Tissue and Cellular Heterogeneity in IPF, Yale Clinical and Translational Science Award, Claude D. Pepper Older Americans Independence Center at Yale
OpenAlex ID: W4385665597