Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1 H NMR Spectroscopy Results From the UK Biobank
Year: 2023
Type: article
Study design: Observational Study
Abstract: Purpose: The purpose of this study was to assess metabolites associated with intraocular pressure (IOP) and inner retina structure. Methods: We cross-sectionally assessed 168 non-fasting plasma metabolites measured by nuclear magnetic resonance (NMR) spectroscopy with IOP (n = 28,195), macular retinal nerve fiber layer thickness (mRNFL; n = 10,584), and macular ganglion cell inner plexiform layer thickness (mGCIPL; n = 10,554) in the UK Biobank. We used multiple linear regression models adjusting for various covariates with probit-transformed metabolite levels as predictors for each outcome. Each estimate represents the difference in outcome variable per standard deviation increase in the probit-transformed metabolite values. We used the number of effective (NEF) tests and false discovery rate (FDR) to adjust for multiple comparisons for metabolites and metabolite classes, respectively. Results: In individual metabolite analysis, multiple amino acids, especially branched-chain amino acids, were associated with lower IOP (-0.12 mm Hg; 95% confidence interval = -0.16 to -0.07; NEF = 2.7E-05). Albumin, 3 hydroxybutyrate, lactate, and several lipids were associated with higher IOP (range = 0.07 to 0.18 mm Hg, NEF = ≤ 0.039). In IOP-adjusted analyses, five HDL-related metabolites were associated with thinner mRNFL (-0.15 microns for all metabolites, NEF = ≤ 0.027), whereas five LDL-related metabolites were associated with thicker mGCIPL (range = 0.17 to 0.20 microns; NEF = ≤ 0.044). In metabolite class analysis, the lipid components of lipoproteins (cholesterol, triglycerides, etc.) were not associated with our outcomes (FDR > 0.2 for all); yet multiple lipoproteins were significantly (FDR < 0.05) associated with all outcomes. Conclusions: Branched-chain amino acids were associated with lower IOP, HDL metabolites were associated with thinner mRNFL, and LDL metabolites were associated with thicker mGCIPL.
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,850
Awards: G1169685992, G1416987869, G151562090, Biochemical Markers in the nurses' Health Study Cohort, G2904619447, Gene-Environment Interactions in Glaucoma, G3602225402, G361298724, Enabling precision management of glaucoma through discovery of underlying biological pathways and clinical prediction tool development, G3964026636, G4376790518, G459566519, G4964662507, G6200764915, G7063308019, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, G7491716587, Premenopausal Hormone Levels and Risk of Breast Cancer, G9000019617, G9000028950, G9000058679, G9000122174, G9000185549, Life Course Cancer Epidemiology Cohort in Women, Core Grant for Vision Research, Cancer Epidemiology Cohort in Male Health Professionals
OpenAlex ID: W4385666870