Sex-dependent influence of LMAN1 on lung function and allergen-induced airway hyperresponsiveness
Year: 2023
Type: conference-abstract
Abstract: We recently reported LMAN1 as a regulatory receptor capable of downregulating NF-kB signaling in response to house dust mite (HDM) in vitro. In this follow up work, we have subjected WT and LMAN1 KO mice to a HDM model of allergic airway inflammation and assessed lung function and airway hyperreactivity (AHR). Given our previous in vitro findings, we had expected worsened disease in the absence of LMAN1. Interestingly, when mice were stratified by sex, we observed that while female, HDM-treated LMAN1 KO mice exhibited signs of enhanced airway narrowing and closure and enhanced AHR compared to their WT counterparts, male, HDM-treated LMAN1 KO mice showed the opposite trend. These sex-dependent effects appeared to be localized to the peripheral airways. We additionally characterized the type and extent of immune cell infiltration into the airway and highlight those features which might account for the gender-biased effects of LMAN1 on lung function in the setting of allergic asthma.
Source: The Journal of Immunology
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4385685467