Year: 2023
Type: letter
Abstract: Benn et al. comment that the hexagonal lattices observed in outer membrane (OM) patches upon the addition of polymyxin might be formed by outer membrane proteins (OMPs). They assume that lipopolysaccharides (LPS) protrude above the OMPs, which might hide the OMPs and prevent them from being imaged by AFM. Furthermore, they speculate that polymyxin somehow orders the LPS molecules, such that the hidden OMP lattice is revealed upon polymyxin addition. Indeed this, or that polymyxin induces other biophysical changes to the membrane, are possible scenarios that could follow from our study 1 and that will require further investigation, possibly with higher temporal or spatial imaging modalities.
Source: Nature Communications
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,290
OpenAlex ID: W4385700234