Mesenchymal stem cell-derived extracellular vesicles: emerging concepts in the treatment of spinal cord injury.
Year: 2023
Type: article
Abstract: Spinal cord injury (SCI) is a prevalent central nervous system disease with a high disability rate, leading to the loss of motor and sensory nerve function. Due to the complex pathophysiology of SCI, more effective clinical treatment strategies are needed. Research has indicated the considerable potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) as a cell-free therapy in SCI repair and regeneration due to their ability to regulate immune cell activity and stimulate damaged neuron regeneration. Moreover, applying MSCs and engineered EVs can fully exploit the potential of MSC-EVs in spinal cord repair. Here, we outline the pathological process of SCI and its current clinical treatment status, summarize the latest MSC-EVs research and its pretreatment and engineering strategies in SCI treatment, and explore MSC-EVs application prospects.
Source: PubMed Central
Authors: Shujun Wang, Chengzhe Du, Guilan Li
Institution: Liaocheng University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: Liaocheng University
OpenAlex ID: W4385715584