The effects of allogeneic and autologous blood transfusion on immune function in patients receiving total hip replacement.
Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate the effects of allogeneic and autologous blood transfusion on immune function and postoperative inflammation in patients after total hip replacement. METHODS: In this retrospective study, the clinical data of 60 patients undergoing total hip arthroplasty through a posterolateral approach were analyzed. The patients were grouped into an autologous blood transfusion group (allo group) (n = 30) and an autologous blood transfusion group (auto-group) (n = 30) according to the treatment they received. All patients did not receive preoperative and intraoperative blood transfusion. The blood collected in the operation area was transfused to the patients in the auto-group with the autotransfusion device and the allogeneic blood was transfused to the patients in the allo-group after the operation. The average amount of blood transfusion was 400 ml. The immune function after blood transfusion was mainly evaluated by natural killer cell cytotoxicity (NKCC) and interleukin-2 (IL-2) using ELISA kits, meanwhile the changes of cellular immune factor levels (differentiation cluster of differentiation, CD) (CD3+, CD4+) and humoral immune factor levels (Immunoglobulin E, IgE) after blood transfusion were determined by flow cytometry. The secondary outcome was postoperative inflammatory response measured by white blood cell (WBC) count, neutrophil percentage (NP) and C-reactive protein (CRP). RESULTS: = 0.0064]. CONCLUSION: Autotransfusion can safely replace allogeneic blood transfusion and reduce the damage of postoperative immune function after total hip arthroplasty.
Source: PubMed Central
Authors: Zong-Zheng Han, Miao Li, Yong Zhang
Institution: Jinzhou Medical University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4385716004