A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)
Year: 2023
Type: article
Abstract: Objective: To delineate the etiology, symptomatology, and treatment of Polycythemia Vera in adults with Sickle Cell Disease. The current review contains a review of the 4 case reports that we found on the topic. To our knowledge, no other case reports exist. Methods: We reviewed the scientific literature to discover case reports that included the topic of PV. We noted consistencies in presentation, evaluation, treatment, and clinical outcomes. Results: We reviewed 4 case reports and a limited number of clinical papers on PV in SCD. We found and reported on consistencies in clinical presentation and the diversity of treatments. We reported hematological, bone marrow, and radiographic findings. Conclusions: There is great variability in the evaluation and treatment of cases of PV in SCD. We advocate for more research and deconstructing the complicated relationship between these two comorbid disorders.
Source: Journal of Clinical Haematology
Authors: Christopher L. Edwards, Sharena Scott, Michaela Boggan, Jordan Meek, W. Jeff Bryson, Alexandria McDougald, Milo Broadnax, Camela S. Barker, Jessica Miller, John J. Sollers, Tanisha Burford, Jonathan Livingston, Elaine Whitworth, Goldie S. Byrd, Kelvin L. Williams, Sherry Eaton, Malik Muhammad, George Cliette, Dana Jones, Brianna Downey, Hilary T. Dietahin, Merrell Turner, Roland Thorpe, Keith Whitfield, Debra O. Parker, Elwood Robinson, Mary Wood, Kenyon Railey, Shiv Sudhakar, Wandy Morel Cubilete, Nirmish Shah
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4385781635