Supplementary Figure S1 from Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Year: 2023
Type: supplementary-materials
Abstract: Additional associations between signatures. A. Distribution of CIN70 by HRD score and genomic scars (NtAI tertiles, AiCna tertiles and HLAMP). B Distribution of RPS by HRD score and genomic scars (NtAI tertiles, AiCna tertiles and HLAMP). C. Distribution of PARPi7 by HRD score and genomic scars (NtAI tertiles, AiCna tertiles and HLAMP). D. Distribution of TILs by HRD score, E. Distribution of ConcensusTME average score by HRD score F. ConsensusTME cell type estimates are highly correlated excluding fibroblasts.Correlation assessed using Spearman correlation. HRD<42 = HRD low; HRD≥42 = HRD high.
Authors: Holly Tovey, Orsolya Sipos, Joel S. Parker, Katherine A. Hoadley, Jelmar Quist, Sarah Kernaghan, Lucy Kilburn, Roberto Salgado, Sherene Loi, Richard D. Kennedy, Ioannis Roxanis, Patrycja Gazinska, Sarah E. Pinder, Judith Bliss, Charles M. Perou, Syed Haider, Anita Grigoriadis, Andrew Tutt, Maggie Chon U Cheang
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4385791578