Work

Molding a PI(3,5)P2 biosensor

Year: 2023

Type: article

Abstract: The lipid phosphatidylinositol 3,5-bisphosphate-PI(3,5)P2-is known to be a key regulator of cellular traffic in health and disease, but its cellular localization was somewhat enigmatic until now, with the discovery of a new PI(3,5)P2 biosensor reported in this issue of JCB by Vines et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202209077).

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202308004

Authors: Claire C. Weckerly, Gerald R.V. Hammond

Institution: University of Pittsburgh

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: The roles of PLD and DGK isoforms in PIP2 homeostasis during PLC signaling, Interinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional Outcomes, G5360857167, G718473728, Directing Membrane Function with Inositol Lipids in Health and Disease