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The collaborative study on the genetics of alcoholism: Sample and clinical data

Year: 2023
Type: article
Abstract: The collaborative study on the genetics of alcoholism (COGA) is a multi-site, multidisciplinary project with the goal of identifying how genes are involved in alcohol use disorder and related outcomes, and characterizing how genetic risk unfolds across development and in conjunction with the environment and brain function. COGA is a multi-generational family-based study in which probands were recruited through alcohol treatment centers, along with a set of community comparison families. Nearly 18,000 individuals from >2200 families have been assessed over a period of over 30 years with a rich phenotypic battery that includes semi-structured psychiatric interviews and questionnaire measures, along with DNA collection and electrophysiological data on a large subset. Participants range in age from 7 to 97, with many having longitudinal assessments, providing a valuable opportunity to study alcohol use and problems across the lifespan. Here we provide an overview of data collection methods for the COGA sample, and details about sample characteristics and comorbidity. We also review key research findings that have emerged from analyses of the COGA data. COGA data are available broadly to researchers, and we hope this overview will encourage further collaboration and use of these data to advance the field.
DOI: 10.1111/gbb.12860
Authors: Danielle M. Dick, Emily Balcke, Vivia McCutcheon, Meredith Francis, Sally Kuo, Jessica Salvatore, Jacquelyn Meyers, Laura J. Bierut, Marc Schuckit, Victor Hesselbrock, Howard J. Edenberg, Bernice Porjesz, COGA Collaborators, Samuel Kuperman, John Kramer, Kathleen Bucholz
Institutions: Rutgers, The State University of New Jersey, Washington University in St. Louis, Virginia Commonwealth University, SUNY Downstate Health Sciences University, University of California San Diego, University of Connecticut, UConn Health, Indiana University Indianapolis, Indiana University School of Medicine, University of Iowa
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,190
Funders: Children's Hospital of Philadelphia, University of Pennsylvania, State University of New York, Washington University in St. Louis, University of Connecticut, National Institutes of Health, SUNY Downstate Medical Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse
OpenAlex ID: W4385827455
FWCI: 4.991
Cites: 139
Cited by: 30
Related to: 10