The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program
Year: 2024
Type: article
Abstract: regulatory T (Treg) cells in non-lymphoid tissues with unique characteristics compared with lymphoid Treg cells. However, tissue Treg cells have not been considered holistically across tissues. Here, we performed a systematic analysis of the Treg cell population residing in non-lymphoid organs throughout the body, revealing shared phenotypes, transient residency, and common molecular dependencies. Tissue Treg cells from different non-lymphoid organs shared T cell receptor (TCR) sequences, with functional capacity to drive multi-tissue Treg cell entry and were tissue-agnostic on tissue homing. Together, these results demonstrate that the tissue-resident Treg cell pool in most non-lymphoid organs, other than the gut, is largely constituted by broadly self-reactive Treg cells, characterized by transient multi-tissue migration. This work suggests common regulatory mechanisms may allow pan-tissue Treg cells to safeguard homeostasis across the body.
Source: Immunity
Institutions: Babraham Institute, University of Cambridge, VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, University of Antwerp, VIB-UAntwerp Center for Molecular Neurology, Kansai Medical University, RIKEN Center for Integrative Medical Sciences, Icahn School of Medicine at Mount Sinai
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $9,350
Funders: Brown University, University of Pittsburgh, Wellcome Trust, Francis Crick Institute, Babraham Institute, Cancer Research UK, University of Cambridge, KU Leuven, Directorate for Biological Sciences, Biotechnology and Biological Sciences Research Council, European Research Council, Instituto de Salud Carlos III, RIKEN, Janssen Pharmaceuticals, H2020 European Research Council
OpenAlex ID: W4399775270