Year: 2023
Type: article
Abstract: To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tissue- and development-specific expression patterns associated with a variety of normal and disease conditions, including cancer pathogenesis. Over the past years, due to their intrinsic stability and resistance to ribonucleases, particular attention has been drawn to their use as reliable diagnostic and prognostic biomarkers in cancer diagnosis, treatment, and prevention. However, there are some critical caveats to their utility in the clinic. Their circular shape limits their annotation and a complete functional elucidation is lacking. This makes their detection and biomedical application still challenging. Herein, we review the current knowledge of circRNA biogenesis and function, and of their involvement in tumorigenesis and potential utility in cancer-targeted therapy.
Source: Oncogene
Authors: Giuseppina Pisignano, David C. Michael, Tanvi H. Visal, Radu Pirlog, Michael Ladomery, George A. Calin
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,490
Awards: G1125512807, TRANSLATING NOVEL DISCOVERIES IN GASTRIC ADENOCARCINOMA BIOLOGY INTO THERAPEUTIC ADVANCES, G1573574303, G24587324, G3052628540, G3195654104, HORMONE REGULATION OF TUMOR MICROENVIRONMENT IN ESTROGEN RECEPTOR-POSITIVE BREAST CANCER BY EXTRACELLULAR VESICLE MICRORNAS, G3865632432, G3909086042, G3966651400, G4119534169, G4377847664, G5086248425, G5680656575, G6344965762, G6439468129, miR-155 targeted therapeutics for precision medicine in lung cancer, G7905850378, G8274656085, G8942739721, SPORE in Brain Cancer
OpenAlex ID: W4385857806