Generation of two induced pluripotent stem cell lines from patients with Down syndrome
Year: 2023
Type: article
Abstract: Down syndrome (DS) is caused by trisomy of Homo sapiens chromosome 21 (HSA21) and is by far the most common chromosomal disorder accompanied by neurodevelopmental disorders and congenital heart disease. Here, we generated two induced pluripotent stem cell (iPSC) lines from two patients with DS. These two lines exhibited normal morphology, trisomy 21 karyotype, pluripotency and differentiation capability into derivatives of three germ layers. The patient-specific iPSC lines arean invaluable resource in research to model DS-related cellular and molecular pathologies and test possible therapeutic strategies for DS.
Source: Stem Cell Research
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,210
Awards: G2168952822, G5170875372, Genome Editing of Human iPSCs to Study Inherited Hypertrophic Cardiomyopathy, Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy, Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling, Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell Multiomics, Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs, Elucidating Anthracycline-Induced Cell Type-Specific Cardiovascular Toxicity with CRISPRi/a Screens
OpenAlex ID: W4386701020