Work

Metabolomic Rewiring in Endocrine Therapy-Resistant Estrogen Receptor Positive Breast Cancer

Year: 2023

Type: article

Abstract: We performed RMA normalization of microarray data and extracted AMPK signature gene expression. The average of AMPK signature was plotted. To get the activity of AMPK signature, we performed Principal Component Analysis (PCA) on gene sets first and then redfine the signature based on Coefficients of PC1. Then again performed PCA on Samples and plotted percentage of Coefficients of PC1 as the activity.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.8253345

Authors: Samanta, Tagari, Kaipparettu, Benny

Institution: Baylor College of Medicine

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4385890542

FWCI:

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Related to: 10