Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders
Year: 2023
Type: article
Abstract: The present review focuses on potential neural mechanisms underlying recovery from psychiatric conditions characterised by impaired impulse control, specifically substance use disorders, gambling disorder, and internet gaming disorder. Existing treatments (both pharmacological and psychological) for these addictions may impact brain processes, and these have been evaluated in neuroimaging studies. Medication challenge and short-term intervention administration will be considered with respect to treatment utility. Main models of addiction (e.g., dual process, reward deficiency syndrome) will be considered in the context of extant data. Additionally, advanced analytic approaches (e.g., machine-learning approaches) will be considered with respect to guiding treatment development efforts. Thus, this narrative review aims to provide directions for treatment development for addictive disorders.
Authors: Gemma Mestre-Bach, Marc N. Potenza
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: diamond
Funders: Universidad Internacional de La Rioja, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1044130170, G1675493566, Functional networks related to cocaine dependence and its treatment and relapse, G5541667, G8154172533, Use of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data, G9000092862, G9000288936, Yale Clinical and Translational Science Award
OpenAlex ID: W4385968765