Preventing Neurocognitive Decline in Adults Aging with HIV: Implications for Practice and Research
Year: 2023
Type: review
Abstract: Mild to moderate forms of neurocognitive impairment persist among people living with HIV (PLWH), despite being virally suppressed on antiretroviral therapy. PLWH are disproportionally impacted by physiological and psychosocial comorbidities compared to those without HIV. As adults live longer with HIV, the neurocognitive burden of physiological and psychosocial stressors can impair everyday functioning and may contribute to the development of neurodegenerative diseases such as Alzheimer's disease. This article outlines neurocognitive consequences of everyday stressors in PLWH. While some lifestyle factors can exacerbate inflammatory processes and promote negative neurocognitive health, novel interventions including the use of cannabinoids may be neuroprotective for aging PLWH who are at risk for elevated levels of inflammation from comorbidities. Studies of integrated neurocognitive rehabilitation strategies targeting lifestyle factors are promising for improving neurocognitive health, and may over time, reduce the risk of Alzheimer's disease in PLWH.
Source: Journal of Alzheimer s Disease
DOI: 10.3233/jad-230203
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1278479687, G1448483502, Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV, An RCT of Speed of Processing Training in Middle-Aged and Older Adults with HIV, Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults with HIV, G6933810696, The Impact of Insomnia on Pain, Physical Function, and Inflammation in HIV, Evaluation of Neurobiological Mechanisms Mediating the Effect of Immune Activation on Neurocognitive Impairment and the Role of Psychosocial Factors Among Women Living with HIV, Neurocognitive Trajectories in Older Adults with COVID-19 in the Deep South
OpenAlex ID: W4385977739