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TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice

Year: 2023

Type: article

Abstract: (Cell Reports 27, 549–560.e1–e6; April 9, 2019) When this article was originally published on April 9, 2019, Figure 1G contained errors in which the RNAscope photos in the contralateral hemisphere were misused from the ipsilateral hemisphere within the group (top right) and group (bottom right). The authors reviewed the raw data and generated new, corrected images. Additionally, contralateral immunoblots of IκBα, p-p65, and actin in Figure 1A as well as TRIM9 and actin in Figure S1B were wrongly cropped from the original full immunoblots. The authors checked the raw data, made the correct crops, and replaced these immunoblots with correct ones. Both corrected figures appear below. The authors sincerely regret this error and any confusion that may have arisen.Figure S1TRIM9 upregulation in mouse brains after stroke. Related to Figure 1. (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT) TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in MiceZeng et al.Cell ReportsApril 09, 2019In BriefNeuroinflammation drives pathology during brain injury. Zeng et al. show that TRIM9 is induced after ischemic insults in young mice, but not old mice, and promotes resolution of neuroinflammation. AAV-mediated TRIM9 therapy in aged mice restricts neuroinflammation and alleviates stroke damage, representing a potential therapeutic target for brain injury. Full-Text PDF Open Access

Source: Cell Reports

DOI: 10.1016/j.celrep.2023.113050