Work

Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels

Year: 2023

Type: article

Abstract: The efficient functionalization of graphene with sulfonic groups using a sustainable approach facilitates the interaction of biomolecules with its surface. The inclusion of these graphene sheets inside a photopolymerized acrylamide-based hydrogel provides a 3D scaffold with viscoelastic behaviour closer to that found in natural tissues. Cell-culture experiments and differentiation assays with SH-SY5Y cells showed that these hybrid hydrogels are non-cytotoxic, thus making them potentially useful as scaffold materials mimicking the extracellular environment.

Source: Nanoscale

DOI: 10.1039/d3nr02689b

Authors: Josué M. Galindo, Irene San-Millán, Carlos A. Castillo-Sarmiento, Inmaculada Ballesteros-Yáñez, M. Antonia Herrero, Sonia Merino, Ester Vázquez

Institution: University of Castilla-La Mancha

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Funders: Graphene Flagship, European Commission, Ministerio de Ciencia, Tecnología e Innovación Productiva, Ministerio de Economía y Competitividad, Junta de Comunidades de Castilla-La Mancha, NextGenerationEU

Awards: G120905174, G229647607, G3325146518, G357246561, G3875504754, G4293000412, G4500366796, G4984673608, Graphene Flagship Core Project 3, G531036588, G5576534733, G7356293473, G750653733, G7576272698, G7606071049

OpenAlex ID: W4386019266

FWCI: 0.29

Cites: 63

Cited by: 5

Related to: 10