In Vitro Testing of the 0.6 M2 SciMed Membrane Oxygenator for Use in Neonatal Extracorporeal Membrane Oxygenation
Year: 1991
Type: article
Abstract: Prior to the introduction of the 0.6 M2 SciMed membrane oxygenator, the 0.8 M2 membrane was the only oxygenator FDA-approved for long-term bypass. The performance of the 0.6 M2 SciMed membrane oxygenator was examined using a modified test protocol suggested by the Association for Advancement of Medical Instrumentation for testing gas exchange devices. Four 0.6 M2 SciMed membrane oxygenators were tested in vitro using filtered ovine blood and a customized test circuit designed to provide a continuous source of deoxygenated, CO2-laden blood. Venous blood delivered to the test membrane had an oxygen saturation of 65 ± 2%. Testing confirmed good oxygenation throughout the manufacturer’s specified blood flow range. Transfer rates of CO2 measured for the 0.6 M2 SciMed membrane oxygenator were comparable to those of the 0.8 M2 membrane up to a blood flow rate of 400 ml/minute. Further increases in blood flow did not augment CO2 transfer rates. Use of the 0.6 M2 SciMed membrane oxygenator for neonatal extracorporeal membrane oxygenation (ECMO) should be limited to the lower blood flow range and to infants not likely to experience significant hypercarbia, if such infants can be accurately identified.
Institutions: George Washington University, Children's National
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4386040649