Year: 2023
Type: article
Abstract: Background:The US Preventive Services Task Force (USPSTF) 2021 updated recommendations on lung cancer screening with chest computed tomography to apply to individuals 50-80 years of age (previously 55-80 years), with a ≥20 pack-year history (previously ≥30), whether currently smoking or quit ≤15 years ago. Despite being at higher risk for lung cancer, persons with HIV (PWH) were not well-represented in the National Lung Screening Trial, which informed the USPSTF 2013 recommendations. It is unknown or unclear how PWH are affected by the 2021 recommendations.Setting:This study was a retrospective analysis of PWH with and without lung cancer in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study.Methods:We identified PWH, ages 40-80 years, who currently or previously smoked, with (cases) and without lung cancer (noncases). The sensitivity and specificity of the old, new, and alternative screening criteria were evaluated in each cohort.Results:We identified 52 women and 19 men with lung cancer and 1950 women and 1599 men without lung cancer. Only 11 women (22%) and 6 men (32%) with lung cancer met 2013 screening criteria; however, more women (22; 44%) and men (12; 63%) met 2021 criteria. Decreased age and tobacco exposure thresholds in women further increased sensitivity of the 2021 criteria.Conclusions:The 2021 USPSTF lung cancer screening recommendations would have resulted in more PWH with lung cancer being eligible for screening at the time of their diagnosis. Further investigation is needed to determine optimal screening criteria for PWH, particularly in women.
DOI: 10.17615/0yha-sg94
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, Gilead Sciences, Georgia Clinical and Translational Science Alliance, National Institutes of Health, Centers for Disease Control and Prevention, Allergan, University of North Carolina at Chapel Hill, University of California, San Francisco, Center for AIDS Research, University of Alabama at Birmingham, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities, Center for AIDS Research, University of North Carolina at Chapel Hill, Clinical and Translational Science Institute, University of California, Los Angeles
Awards: G1034546755, G12089860, Patient-Oriented Research and Mentoring in HIV-associated Pulmonary Diseases, G1296759572, G1787625665, G183157880, G1849940085, G1913134163, G2008237588, G2127051194, G2334180555, G255204022, G2908277772, G30074556, G311558797, G3630727822, G3671922257, G3869857964, G4016133911, G4044828089, G4391827178, G4535678174, G456742281, G5078796989, G521591464, G5691055145, G5900455136, G6745172908, G6990385686, G775892330, G7807729167, Johns Hopkins Institute for Clinical and Translational Research, G9000016284, G9000030772, G9000039899, G9000080293, G9000082816, G9000102070, G9000108991, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4386042898