Work

PRS-ing Forward to Identify Genetic Risk in Idiopathic Pulmonary Fibrosis

Year: 2023

Type: article

Abstract: bulk transcriptomic data.Although the authors undertook a stringent approach to replicating their results, it is notable that even for the set of 475 persistently altered smoking genes that achieved significance across each study time point, only 41% (n = 195) of these genes were also significant in both independent replication cohorts.This level of replication is not surprising for transcriptomic data, which captures many complex signals but can be susceptible to confounding in both cross-sectional and longitudinal study designs.Although multiple stages of replication in this study provide confidence in the 195 fully replicated smoking-associated genes, further studies will be necessary to tease out adaptive versus maladaptive responses to cigarette smoke as well as the lingering consequences of smoke exposure on human health.

Source: American Journal of Respiratory and Critical Care Medicine

DOI: 10.1164/rccm.202308-1373ed

Authors: Timothy S. Blackwell, Gunnar Gudmundsson

Institutions: Vanderbilt University, Nashville VA Medical Center, Vanderbilt University Medical Center, University of Iceland, National University Hospital of Iceland

Language: English

Topic: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, National Heart, Lung, and Blood Institute