FIGURE 6 from Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma
Year: 2023
Type: other
Abstract: Intratumoral USP6 expression induces systemic activation of NK and myeloid cells. RAG2−/− mice were xenografted with USP6/A673 and treated with or without dox, or not xenografted (Control, Ctrl). PB was collected approximately 3 weeks later, and subjected to flow cytometry. Abundance, early/late activation, proliferative potential, and cytotoxic activity were assessed using the indicated markers in the entire NK population (NK1.1+/NKp46+; A), and in NK cell subpopulations as defined by levels of CD27 and CD11b (B; see also Supplementary Fig. S6 for definition of subsets). C, Abundance of myeloid populations (among the CD11b+/CD45+ cells) as defined by the indicated markers (Ctrl n = 4, −dox n = 6, +dox n = 9).
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4386069964