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FIGURE 4 from Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma

Year: 2023

Type: other

Abstract: USP6 upregulates NK cell-activating ligands on Ewing sarcoma cells in vitro and in vivo.A, Activating and inhibitory receptors on NK cells, and their cognate ligands on target cells. B, USP6/A673 or USP6/RD-ES cells were treated with or without dox, and surface levels of the indicated markers was quantified by flow cytometry (n ≥ 3 experiments per marker). C, USP6/A673 xenografts from RAG2−/− mice were digested and subjected to flow cytometry to detect surface levels of the indicated markers (−dox n = 6, +dox n = 8).

DOI: 10.1158/2767-9764.24008255.v1

Authors: Kanika Jain, Ian C. Henrich, Laura Quick, Robert Young, Shreya Mondal, Andre M. Oliveira, Gerd A. Blobel, Margaret M. Chou

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4386073034

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