Work

Automated production of 11C‐labeled carboxylic acids and esters via “in‐loop” 11C‐carbonylation using GE FX synthesis modules

Year: 2023

Type: article

Abstract: An in‐loop 11C‐carbonylation process for the radiosynthesis of 11C‐carboxylic acids and esters from halide precursors has been developed. The reaction proceeds at room temperature under mild conditions and enables 11C‐carbonylation of both electron deficient and electron rich (hetero)aromatic halides to provide 11C‐carboxylic acids and esters in good to excellent radiochemical yields, high radiochemical purity, and excellent molar activity. The process has been fully automated using commercial radiochemistry synthesis modules, and application to clinical production is demonstrated via validated cGMP radiosyntheses of [11C]bexarotene and [11C]acetoacetic acid.

Source: Journal of Labelled Compounds and Radiopharmaceuticals

DOI: 10.1002/jlcr.4058

Authors: Tanpreet Kaur, Jay S. Wright, Bradford D. Henderson, Jonathan Godinez, Xia Shao, Peter J. H. Scott

Institutions: University of Michigan, Michigan Medicine

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,450

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering