Work

Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity

Year: 2023

Type: preprint

Study design: Observational Study

Abstract: We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2023.08.17.553767

Authors: Alberto Moreno, Kelly Manning, Maryam I. Azeem, Ajay K. Nooka, Madison Ellis, Renee Julia Manalo, Jeffrey M. Switchenko, Bushra Wali, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar, Mehul S. Suthar

Institutions: Emory University, Emory National Primate Research Center, Children's Healthcare of Atlanta, Winship Cancer Institute

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Amgen, Celgene, Emory University, Children's Healthcare of Atlanta, TG Therapeutics, Incyte, National Institutes of Health, Genentech, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: B cells in autoimmunity following checkpoint blockade therapy, G1434356123, G1489263424, G1636177350, G3449227105, G4587763221, G4885028645, G5514976981, B cell depletion to prevent autoimmunity, G740460624, G7605218473, G8574682048, G9000035552, G9000118633, Winship Cancer Institute Cancer Center Support Grant, Vaccine and Infection Induced Immunity in the Young and Aged

OpenAlex ID: W4386097107

Cites: 15

Cited by:

Related to: 10