Pretreatment and interventional parameters predict excellent recanalization of large vessel occlusion in patients with acute ischemic stroke
Year: 2023
Type: preprint
Study design: Observational Study
Abstract: Background In patients with acute ischemic stroke secondary to large vessel occlusion (AIS-LVO), improved functional outcomes have been reported in patients who achieve Modified Thrombolysis In Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b. We aimed to determine pretreatment and interventional variables that could predict achieving mTICI 2c/3 over 2b reperfusion in patients who underwent technically successful mechanical thrombectomy (MT). Methods In this retrospective study, consecutive AIS patients with anterior circulation LVO who underwent MT and achieved recanalization with mTICI 2b/2c/3 were included. We evaluated the association between pretreatment clinical and imaging variables and interventional parameters in patients who achieved mTICI 2c/3 vs. 2b using logistic regression and ROC analyses. Results From 5/11/2019 to 10/09/2022, 149 consecutive patients met our inclusion criteria (median 70 years old [IQR 65 - 78.5], 57.7% female). Adjusted multivariate regression analyses showed that patients with excellent recanalization had lower admission NIHSS (aOR 0.93, p = 0.036), were less likely to have a history of diabetes mellitus (DM) (aOR 0.42, p = 0.050) and prior stroke (aOR 0.27, p = 0.007), had a cerebral blood volume (CBV) index >= 0.7 (aOR 3.75, p = 0.007), and were more likely to achieve excellent recanalization with aspiration alone (aOR 2.89, p = 0.012). A multivariate logistic regression model comprising these independent factors predicted mTICI 2c/3 with an AUC 0.79 (95% CI: 0.68-0.86; p < 0.001), sensitivity of 94%; specificity of 41%. Conclusion Robust collateral status (CS) defined by CBV index >= 0.7, absence of DM and prior stroke, lower initial stroke severity, and direct aspiration are all predictive of excellent recanalization in successfully recanalized AIS-LVO patients. Our findings highlight the prognostic implications of robust CS, DM and stroke prevention, as well as use of aspiration alone in maximizing the likelihood of excellent recanalization.
Source: medRxiv
Authors: Vivek Yedavalli, Manisha Koneru, Meisam Hoseinyazdi, Cynthia Greene, Karen Copeland, Risheng Xu, Licia Luna, Justin Caplan, Adam Dmytriw, Adrien Guenego, Jeremy Heit, Gregory Albers, Max Wintermark, Fernando Gonzalez, Victor Urrutia, Judy Huang, Richard Leigh, Elisabeth Marsh, Rafael Llinas, Argye Hillis, Kambiz Nael
Institutions: Johns Hopkins University, Johns Hopkins Medicine, Cooper Medical School of Rowan University, Harvard University, Massachusetts General Hospital, Erasmus Hospital, Stanford Medicine, Stanford University, The University of Texas MD Anderson Cancer Center, University of California, Los Angeles
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4386122158