Impedance Rhythms in Human Limbic System

Year: 2023

Type: article

Abstract: ABSTRACT Brain impedance is a fundamental electrical property that depends on tissue extracellular volume. We tracked impedance, behavioral state, and epileptiform activity in humans using an investigational device and identified behavioral state dependent impedance oscillations spanning hours to weeks in amygdala, hippocampus, and thalamus. Impedance reaches a minimum in slow wave sleep, is intermediate in rapid-eye-movement sleep and maximal during wakefulness consistent with previously observed extracellular volume changes in rodent glymphatic system.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.0241-23.2023

Institutions: Mayo Clinic, International Clinical Research Center, St. Anne's University Hospital Brno, St. Anne's University Hospital Brno, Brno University of Technology, Czech Technical University in Prague, University of Oxford, MRC Brain Network Dynamics Unit, Medical Research Council

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Mayo Clinic, Pfizer, České Vysoké Učení Technické v Praze, National Institutes of Health, Defense Advanced Research Projects Agency, Advanced Research Projects Agency, Research Center for Informatics, Czech Technical University in Prague, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke

Awards: G1066744267, G1600399044, G1808078543, G2242485319, G2875759400, G2892353575, G3450089018, G3792328359, Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy, The glial mechanism for electrical brain stimulation, G5970536809, G8044165126, G9000051549

OpenAlex ID: W4386127426