Work

Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage

Year: 2023

Type: article

Abstract: Hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) was applied for the first time to image and quantify the uptake and metabolism of [2-13C]pyruvate in the human brain to provide new metabolic information on cerebral energy metabolism. HP [2-13C]pyruvate was injected intravenously and imaged in 5 healthy human volunteer exams with whole brain coverage in a 1-minute acquisition using a specialized spectral-spatial multi-slice echoplanar imaging (EPI) pulse sequence to acquire 13C-labeled volumetric and dynamic images of [2-13C]pyruvate and downstream metabolites [5-13C]glutamate and [2-13C]lactate. Metabolic ratios and apparent conversion rates of pyruvate-to-lactate (kPL) and pyruvate-to-glutamate (kPG) were quantified to investigate simultaneously glycolytic and oxidative metabolism in a single injection.

Source: NeuroImage

DOI: 10.1016/j.neuroimage.2023.120350

Authors: Brian T. Chung, Yaewon Kim, Jeremy W. Gordon, Hsin-Yu Chen, Adam W. Autry, Philip M. Lee, Jasmine Y. Hu, Chou T. Tan, Chris Suszczynski, Susan M. Chang, Javier E. Villanueva-Meyer, Robert A. Bok, Peder E.Z. Larson, Duan Xu, Yan Li, Daniel B. Vigneron

Institutions: University of California, San Francisco, University of California, Berkeley, MilliporeSigma (United States)

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,450

Funders: National Institutes of Health, University of California, San Francisco, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI Methods, G5800834670, Multimodality Neuroimaging Evaluation of Cognitive Functioning in Lower Grade Astrocytoma, Quantitative Steady-State and Dynamic Metabolic MRI for Evaluating Patients with Glioma, Hyperpolarized MRI Technology Resource Center, Imaging and Genomic Signatures of Brain Tumor Heterogeneity and Evolution to Optimize Patient Management

OpenAlex ID: W4386157381

FWCI: 1.648

Cites: 50

Cited by: 10

Related to: 10