Year: 2023
Type: article
Abstract: SignificancePeripheral nerves are viscoelastic tissues with unique elastic characteristics. Imaging of peripheral nerve elasticity is important in medicine, particularly in the context of nerve injury and repair. Elasticity imaging techniques provide information about the mechanical properties of peripheral nerves, which can be useful in identifying areas of nerve damage or compression, as well as assessing the success of nerve repair procedures.AimWe aim to assess the feasibility of Brillouin microspectroscopy for peripheral nerve imaging of elasticity, with the ultimate goal of developing a new diagnostic tool for peripheral nerve injury in vivo.ApproachViscoelastic properties of the peripheral nerve were evaluated with Brillouin imaging spectroscopy.ResultsAn external stress exerted on the fixed nerve resulted in a Brillouin shift. Quantification of the shift enabled correlation of the Brillouin parameters with nerve elastic properties.ConclusionsBrillouin microscopy provides sufficient sensitivity to assess viscoelastic properties of peripheral nerves.
Source: Neurophotonics
Authors: Vsevolod Cheburkanov, Junwei Du, David Brogan, Mikhail Y. Berezin, Vladislav V. Yakovlev
Institutions: Texas A&M University, Washington University in St. Louis
Language: English
Subfield: Biophysics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,675
Funders: National Science Foundation, National Aeronautics and Space Administration, National Institutes of Health, U.S. Food and Drug Administration, Biomedical Advanced Research and Development Authority, National Cancer Institute, National Institute of General Medical Sciences, Division of Civil, Mechanical and Manufacturing Innovation, Air Force Office of Scientific Research, Army Research Laboratory
Awards: G1523888516, G1643905599, G2998068056, G3546748347, G36446433, G3722112304, G3871258473, G392768340, G4330005305, G5146009257, Experimental and Theoretical Study of Femtosecond Microscale 3D Light Field Projection and Its Application in Multiphoton 3D Light Field Lithography, G5259331294, G567078433, G5729145195, G6125686523, G6946752457, G7456149010, G762138976, G7658023295, Brillouin Microscope for Biomedical Research, G8359087180, Sensing local nano-environment with coherent Raman microspectroscopy, G9000197781, G9000353034
OpenAlex ID: W4386189072