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Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury

Year: 2023

Type: erratum

Abstract: The authors apologize for an error in Fig. 1 s. The image of Cnn1 is a duplication of the image of Acta2. The corrected Fig. 1 is shown below. Fig. 1: Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury. a Immunoblot of Med23 in various tissues isolated from Med23 sm−/− and control mice. Aorta, mesenteric arteries ( b ) and aortic lumen area ( c ) in Med23 sm−/− and control mice. d Blood pressure of Med23 sm−/− and control mice on normal or high salt diets. e Isometric contraction of aorta rings prepared from Med23 sm−/− and control mice (60 mM KCl). f Dose-response curves for PE-induced contraction in Med23 sm−/− and control aortas (60 mM KCl). g Representative H/E staining of femoral arteries from Med23 sm−/− and control mice. h Representative elastin staining of femoral arteries from Med23 sm−/− and control mice. Intima-to-media ratio ( i ) and restenosis index ( j ) of femoral arteries harvested from Med23 sm−/− and control mice. k Cell proliferation of VSMCs isolated from the aorta. l Cell proliferation of A7R5 cells after viral-mediated siRNA knockdown of Med23 . Wound healing assay in the presence of either 20% FBS ( m ) or 20 ng/mL PDGFbb ( n ). o Immunostaining of Med23 sm−/− VSMCs. p Expression levels of SMC genes and growth-related genes in the isolated VSMCs. q , r RNA-seq analysis of the aorta samples from Med23 sm−/− mice. Western blot ( s ) and real-time PCR ( t ) of isolated VSMCs from control and Med23 sm−/− mice. NS, nucleostemin. Data are presented as means ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, vs control. Full size image

Source: Cell Discovery

DOI: 10.1038/s41421-023-00594-4