Work

MAVS is a double-edged sword

Year: 2023

Type: article

Abstract: It is well known that cancer cells can modulate expression of a variety of genes to gain an adaptive advantage. Many such changes affect the mitochondria, as altered metabolism and metabolic plasticity is one avenue through which cancers can enhance proliferation and survival.1 Furthermore, cancer cells can also evade immune system responses for a survival advantage.2 Trishna et al. have discovered a functional role of mitochondrial antiviral signaling protein, MAVS, in multiple types of cancer, implicating MAVS as a common target in malignancies.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2023.08.012

Authors: Christina Huang, Jack L. Arbiser

Institution: Thomas Jefferson University

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900